Metabolism:

Obese Mice Lacking Inducible Nitric Oxide Synthase Are Sensitized to the Metabolic Actions of Peroxisome Proliferator–Activated Receptor- Agonism

Patrice Dallaire, Kerstin Bellmann, Mathieu Laplante, Stéphanie Gélinas, Carolina Centeno-Baez, Patrice Penfornis, Marie-Line Peyot, Martin G. Latour, Julien Lamontagne, Maria E. Trujillo, Philipp E. Scherer, Marc Prentki, Yves Deshaies, and André Marette
Diabetes 2008 57: 1999 -2011. First published on May 5, 2008 as 10.2337/db08-0540 [Abstract] [Full Text] [PDF] Online-Only Appendix  

Partial Resistance to Peroxisome Proliferator–Activated Receptor- Agonists in ZDF Rats Is Associated With Defective Hepatic Mitochondrial Metabolism

Santhosh Satapati, TianTeng He, Takeshi Inagaki, Matthew Potthoff, Matthew E. Merritt, Victoria Esser, David J. Mangelsdorf, Steven A. Kliewer, Jeffrey D. Browning, and Shawn C. Burgess
Diabetes 2008 57: 2012 -2021. First published on May 9, 2008 as 10.2337/db08-0226 [Abstract] [Full Text] [PDF]  

Relationship of Abdominal Visceral and Subcutaneous Adipose Tissue With Lipoprotein Particle Number and Size in Type 2 Diabetes

Susan Sam, Steven Haffner, Michael H. Davidson, Ralph B. D'Agostino, Sr., Steven Feinstein, George Kondos, Alfonso Perez, and Theodore Mazzone
Diabetes 2008 57: 2022 -2027. First published on May 9, 2008 as 10.2337/db08-0157 [Abstract] [Full Text] [PDF]  

Cannabinoid Type 1 Receptor Blockade Promotes Mitochondrial Biogenesis Through Endothelial Nitric Oxide Synthase Expression in White Adipocytes

Laura Tedesco, Alessandra Valerio, Cristina Cervino, Annalisa Cardile, Claudio Pagano, Roberto Vettor, Renato Pasquali, Michele O. Carruba, Giovanni Marsicano, Beat Lutz, Uberto Pagotto, and Enzo Nisoli
Diabetes 2008 57: 2028 -2036. First published on May 13, 2008 as 10.2337/db07-1623 [Abstract] [Full Text] [PDF] Online-Only Appendix  

Consequences of Lipid Droplet Coat Protein Downregulation in Liver Cells: Abnormal Lipid Droplet Metabolism and Induction of Insulin Resistance

Ming Bell, Hong Wang, Hui Chen, John C. McLenithan, Da-Wei Gong, Rong-Zee Yang, Daozhan Yu, Susan K. Fried, Michael J. Quon, Constantine Londos, and Carole Sztalryd
Diabetes 2008 57: 2037 -2045. First published on May 16, 2008 as 10.2337/db07-1383 [Abstract] [Full Text] [PDF] Online-Only Appendix  

Arcuate Glucagon-Like Peptide 1 Receptors Regulate Glucose Homeostasis but Not Food Intake

Darleen A. Sandoval, Didier Bagnol, Stephen C. Woods, David A. D'Alessio, and Randy J. Seeley
Diabetes 2008 57: 2046 -2054. First published on May 16, 2008 as 10.2337/db07-1824 [Abstract] [Full Text] [PDF]  

The Human Lipodystrophy Gene BSCL2/Seipin May Be Essential for Normal Adipocyte Differentiation

Victoria A. Payne, Neil Grimsey, Antoinette Tuthill, Sam Virtue, Sarah L. Gray, Edoardo Dalla Nora, Robert K. Semple, Stephen O'Rahilly, and Justin J. Rochford
Diabetes 2008 57: 2055 -2060. First published on May 5, 2008 as 10.2337/db08-0184 [Abstract] [Full Text] [PDF] Online-Only Abstract  

Hypothalamic Protein Kinase C Regulates Glucose Production

Rachel Ross, Penny Y.T. Wang, Madhu Chari, Carol K.L. Lam, Liora Caspi, Hiraku Ono, Evan D. Muse, Xiaosong Li, Roger Gutierrez-Juarez, Peter E. Light, Gary J. Schwartz, Luciano Rossetti, and Tony K.T. Lam
Diabetes 2008 57: 2061 -2065. First published on May 28, 2008 as 10.2337/db08-0206 [Abstract] [Full Text] [PDF]  

Signal Transduction:

siRNA-Mediated Reduction of Inhibitor of Nuclear Factor-B Kinase Prevents Tumor Necrosis Factor-–Induced Insulin Resistance in Human Skeletal Muscle

Reginald L. Austin, Anna Rune, Karim Bouzakri, Juleen R. Zierath, and Anna Krook
Diabetes 2008 57: 2066 -2073. First published on April 28, 2008 as 10.2337/db07-0763 [Abstract] [Full Text] [PDF]  

Autocrine IGF-1 Action in Adipocytes Controls Systemic IGF-1 Concentrations and Growth

Nora Klöting, Linda Koch, Thomas Wunderlich, Matthias Kern, Karen Ruschke, Wilhelm Krone, Jens C. Brüning, and Matthias Blüher
Diabetes 2008 57: 2074 -2082. First published on April 28, 2008 as 10.2337/db07-1538 [Abstract] [Full Text] [PDF]  

Impact of Oxidative Stress and Peroxisome Proliferator–Activated Receptor Coactivator-1 in Hepatic Insulin Resistance

Naoki Kumashiro, Yoshifumi Tamura, Toyoyoshi Uchida, Takeshi Ogihara, Yoshio Fujitani, Takahisa Hirose, Hideki Mochizuki, Ryuzo Kawamori, and Hirotaka Watada
Diabetes 2008 57: 2083 -2091. First published on May 16, 2008 as 10.2337/db08-0144 [Abstract] [Full Text] [PDF]  

Obesity Studies:

Brain Apolipoprotein E: an Important Regulator of Food Intake in Rats

Ling Shen, Patrick Tso, Stephen C. Woods, Deborah J. Clegg, Kyna L. Barber, Katherine Carey, and Min Liu
Diabetes 2008 57: 2092 -2098. First published on June 16, 2008 as 10.2337/db08-0291 [Abstract] [Full Text] [PDF]  

Immunology and Transplantation:

T-Cell Promiscuity in Autoimmune Diabetes

Li Li, Bo Wang, Jeffrey A. Frelinger, and Roland Tisch
Diabetes 2008 57: 2099 -2106. First published on May 20, 2008 as 10.2337/db08-0383 [Abstract] [Full Text] [PDF]  

Thymic Stromal Lymphopoietin and Thymic Stromal Lymphopoietin–Conditioned Dendritic Cells Induce Regulatory T-Cell Differentiation and Protection of NOD Mice Against Diabetes

Gilles Besin, Simon Gaudreau, Michaël Ménard, Chantal Guindi, Gilles Dupuis, and Abdelaziz Amrani
Diabetes 2008 57: 2107 -2117. First published on May 13, 2008 as 10.2337/db08-0171 [Abstract] [Full Text] [PDF]  

Extracellular High-Mobility Group Box 1 Acts as an Innate Immune Mediator to Enhance Autoimmune Progression and Diabetes Onset in NOD Mice

Junyan Han, Jinxin Zhong, Wenzhong Wei, Ying Wang, Yafei Huang, Ping Yang, Sharad Purohit, Zheng Dong, Mong-Heng Wang, Jin-Xiong She, Feili Gong, David M. Stern, and Cong-Yi Wang
Diabetes 2008 57: 2118 -2127. First published on May 13, 2008 as 10.2337/db07-1499 [Abstract] [Full Text] [PDF] Online-Only Appendix  

Pancreatic Duct Cells in Human Islet Cell Preparations Are a Source of Angiogenic Cytokines Interleukin-8 and Vascular Endothelial Growth Factor

Babak Movahedi, Conny Gysemans, Daniel Jacobs-Tulleneers-Thevissen, Chantal Mathieu, and Daniel Pipeleers
Diabetes 2008 57: 2128 -2136. First published on May 20, 2008 as 10.2337/db07-1705 [Abstract] [Full Text] [PDF]  

Islet Studies:

PANIC-ATTAC: A Mouse Model for Inducible and Reversible β-Cell Ablation

Zhao V. Wang, James Mu, Todd D. Schraw, Laurent Gautron, Joel K. Elmquist, Bei B. Zhang, Michael Brownlee, and Philipp E. Scherer
Diabetes 2008 57: 2137 -2148. First published on May 9, 2008 as 10.2337/db07-1631 [Abstract] [Full Text] [PDF] Online-Only Appendix  

Pathophysiology:

Activation of Peroxisome Proliferator–Activated Receptor β/ Inhibits Lipopolysaccharide-Induced Cytokine Production in Adipocytes by Lowering Nuclear Factor-B Activity via Extracellular Signal–Related Kinase 1/2

Ricardo Rodríguez-Calvo, Lucía Serrano, Teresa Coll, Norman Moullan, Rosa M. Sánchez, Manuel Merlos, Xavier Palomer, Juan C. Laguna, Liliane Michalik, Walter Wahli, and Manuel Vázquez-Carrera
Diabetes 2008 57: 2149 -2157. First published on April 28, 2008 as 10.2337/db08-0176 [Abstract] [Full Text] [PDF]  

Altered Calcium Homeostasis Does Not Explain the Contractile Deficit of Diabetic Cardiomyopathy

Lin Zhang, Mark B. Cannell, Anthony R.J. Phillips, Garth J.S. Cooper, and Marie-Louise Ward
Diabetes 2008 57: 2158 -2166. First published on May 20, 2008 as 10.2337/db08-0140 [Abstract] [Full Text] [PDF]  

Complications:

Exposure to Maternal Diabetes Induces Salt-Sensitive Hypertension and Impairs Renal Function in Adult Rat Offspring

Touria Nehiri, Jean-Paul Duong Van Huyen, Mélanie Viltard, Céline Fassot, Didier Heudes, Nicole Freund, Georges Deschênes, Pascal Houillier, Patrick Bruneval, and Martine Lelièvre-Pégorier
Diabetes 2008 57: 2167 -2175. First published on April 28, 2008 as 10.2337/db07-0780 [Abstract] [Full Text] [PDF]  

Heritability of Proliferative Diabetic Retinopathy

Kustaa Hietala, Carol Forsblom, Paula Summanen, Per-Henrik Groop on behalf of the FinnDiane Study Group
Diabetes 2008 57: 2176 -2180. First published on April 28, 2008 as 10.2337/db07-1495 [Abstract] [Full Text] [PDF] Online-Only Appendix  

Protein Kinase C- Mediates Neuronal Apoptosis in the Retinas of Diabetic Rats via the Akt Signaling Pathway

Young-Hee Kim, Yoon-Sook Kim, Chang-Hwan Park, In-Yong Chung, Ji-Myong Yoo, Jae-Geun Kim, Byung-Ju Lee, Sang-Soo Kang, Gyeong-Jae Cho, and Wan-Sung Choi
Diabetes 2008 57: 2181 -2190. First published on April 28, 2008 as 10.2337/db07-1431 [Abstract] [Full Text] [PDF]  

Angiotensin II Type 1 Receptor Signaling Contributes to Synaptophysin Degradation and Neuronal Dysfunction in the Diabetic Retina

Toshihide Kurihara, Yoko Ozawa, Norihiro Nagai, Kei Shinoda, Kousuke Noda, Yutaka Imamura, Kazuo Tsubota, Hideyuki Okano, Yuichi Oike, and Susumu Ishida
Diabetes 2008 57: 2191 -2198. First published on May 16, 2008 as 10.2337/db07-1281 [Abstract] [Full Text] [PDF]  

Pharmacology and Therapeutics:

Pck1 Gene Silencing in the Liver Improves Glycemia Control, Insulin Sensitivity, and Dyslipidemia in db/db Mice

Alicia G. Gómez-Valadés, Andrés Méndez-Lucas, Anna Vidal-Alabró, Francese X. Blasco, Miguel Chillon, Ramon Bartrons, Jordi Bermúdez, and José C. Perales
Diabetes 2008 57: 2199 -2210. First published on April 28, 2008 as 10.2337/db07-1087 [Abstract] [Full Text] [PDF] Online-Only Appendix  

Selective Small-Molecule Agonists of G Protein–Coupled Receptor 40 Promote Glucose-Dependent Insulin Secretion and Reduce Blood Glucose in Mice

Carina P. Tan, Yue Feng, Yun-Ping Zhou, George J. Eiermann, Aleksandr Petrov, Changyou Zhou, Songnian Lin, Gino Salituro, Peter Meinke, Ralph Mosley, Taro E. Akiyama, Monica Einstein, Sanjeev Kumar, Joel P. Berger, Sander G. Mills, Nancy A. Thornberry, Lihu Yang, and Andrew D. Howard
Diabetes 2008 57: 2211 -2219. First published on May 13, 2008 as 10.2337/db08-0130 [Abstract] [Full Text] [PDF]  

Genetics:

Association Analysis in African Americans of European-Derived Type 2 Diabetes Single Nucleotide Polymorphisms From Whole-Genome Association Studies

Joshua P. Lewis, Nicholette D. Palmer, Pamela J. Hicks, Michele M. Sale, Carl D. Langefeld, Barry I. Freedman, Jasmin Divers, and Donald W. Bowden
Diabetes 2008 57: 2220 -2225. First published on April 28, 2008 as 10.2337/db07-1319 [Abstract] [Full Text] [PDF]  

Implication of Genetic Variants Near TCF7L2, SLC30A8, HHEX, CDKAL1, CDKN2A/B, IGF2BP2, and FTO in Type 2 Diabetes and Obesity in 6,719 Asians

Maggie C.Y. Ng, Kyong Soo Park, Bermseok Oh, Claudia H.T. Tam, Young Min Cho, Hyoung Doo Shin, Vincent K.L. Lam, Ronald C.W. Ma, Wing Yee So, Yoon Shin Cho, Hyung-Lae Kim, Hong Kyu Lee, Juliana C.N. Chan, and Nam H. Cho
Diabetes 2008 57: 2226 -2233. First published on May 9, 2008 as 10.2337/db07-1583 [Abstract] [Full Text] [PDF] Online-Only Appendix  

Role of the Transcription Factor Sox4 in Insulin Secretion and Impaired Glucose Tolerance

Michelle Goldsworthy, Alison Hugill, Helen Freeman, Emma Horner, Kenju Shimomura, Debora Bogani, Guido Pieles, Vesna Mijat, Ruth Arkell, Shoumo Bhattacharya, Frances M. Ashcroft, and Roger D. Cox
Diabetes 2008 57: 2234 -2244. First published on May 13, 2008 as 10.2337/db07-0337 [Abstract] [Full Text] [PDF] Online-Only Appendix  

Common Variation in the Fat Mass and Obesity-Associated (FTO) Gene Confers Risk of Obesity and Modulates BMI in the Chinese Population

Yi-Cheng Chang, Pi-Hua Liu, Wei-Jei Lee, Tien-Jyun Chang, Yi-Der Jiang, Hung-Yuan Li, Shan-Shan Kuo, Kuang-Chin Lee, and Lee-Ming Chuang
Diabetes 2008 57: 2245 -2252. First published on May 16, 2008 as 10.2337/db08-0377 [Abstract] [Full Text] [PDF]  

The Common P446L Polymorphism in GCKR Inversely Modulates Fasting Glucose and Triglyceride Levels and Reduces Type 2 Diabetes Risk in the DESIR Prospective General French Population

Martine Vaxillaire, Christine Cavalcanti-Proença, Aurélie Dechaume, Jean Tichet, Michel Marre, Beverley Balkau, Philippe Froguel for the DESIR Study Group
Diabetes 2008 57: 2253 -2257. First published on June 12, 2008 as 10.2337/db07-1807 [Abstract] [Full Text] [PDF] Online-Only Appendix  

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