Perspectives in Diabetes:

Immunomodulation by Mesenchymal Stem Cells: A Potential Therapeutic Strategy for Type 1 Diabetes

Reza Abdi, Paolo Fiorina, Chaker N. Adra, Mark Atkinson, and Mohamed H. Sayegh
Diabetes 2008 57: 1759 -1767. First published on July 1, 2008 as 10.2337/db08-0180 [Abstract] [Full Text] [PDF]  

Neurophysiological Pathways to Obesity: Below Awareness and Beyond Individual Control

Deborah A. Cohen
Diabetes 2008 57: 1768 -1773. First published on July 1, 2008 as 10.2337/db08-0163 [Abstract] [Full Text] [PDF]  

Protein Kinase C Function in Muscle, Liver, and β-Cells and Its Therapeutic Implications for Type 2 Diabetes

Carsten Schmitz-Peiffer and Trevor J. Biden
Diabetes 2008 57: 1774 -1783. [Extract] [Full Text] [PDF]  

Commentaries:

The Pol-e-Pill Finally Arrives

James A. Levine and Ronald M. Davis
Diabetes 2008 57: 1784 -1785. [Extract] [Full Text] [PDF]  

Obesity: Increasing Awareness of Novel Environmental Factors

Kevin D. Niswender and Bettina M. Beech
Diabetes 2008 57: 1786 -1787. [Extract] [Full Text] [PDF]  

Low-Affinity Major Histocompatibility Complex–Binding Peptides in Type 1 Diabetes

Eddie A. James and William W. Kwok
Diabetes 2008 57: 1788 -1789. [Extract] [Full Text] [PDF]  

New Methodologies and Databases:

Glucose Metabolism In Vivo in Four Commonly Used Inbred Mouse Strains

Eric D. Berglund, Candice Y. Li, Greg Poffenberger, Julio E. Ayala, Patrick T. Fueger, Shannon E. Willis, Marybeth M. Jewell, Alvin C. Powers, and David H. Wasserman
Diabetes 2008 57: 1790 -1799. First published on April 8, 2008 as 10.2337/db07-1615 [Abstract] [Full Text] [PDF]  

Metabolism:

Plasma C5 Glucose–to–²H₂O Ratio Does Not Provide an Accurate Assessment of Gluconeogenesis During Hyperinsulinemic-Euglycemic Clamps in Either Nondiabetic or Diabetic Humans

Rita Basu, Visvanathan Chandramouli, Betty Dicke, Bernard R. Landau, and Robert A. Rizza
Diabetes 2008 57: 1800 -1804. First published on April 16, 2008 as 10.2337/db08-0195 [Abstract] [Full Text] [PDF] Online-Only Appendix  

Signal Transduction:

Human Adenovirus Type 36 Enhances Glucose Uptake in Diabetic and Nondiabetic Human Skeletal Muscle Cells Independent of Insulin Signaling

Zhong Q. Wang, William T. Cefalu, Xian H. Zhang, Yongmei Yu, Jianhua Qin, Leslie Son, Pamela M. Rogers, Nazar Mashtalir, Justin R. Bordelon, Jianping Ye, and Nikhil V. Dhurandhar
Diabetes 2008 57: 1805 -1813. First published on April 16, 2008 as 10.2337/db07-1313 [Abstract] [Full Text] [PDF]  

Activation of Estrogen Receptor Is Crucial for Resveratrol-Stimulating Muscular Glucose Uptake via Both Insulin-Dependent and -Independent Pathways

Jen-Ying Deng, Po-Shiuan Hsieh, Jiung-Pang Huang, Long-Sheng Lu, and Li-Man Hung
Diabetes 2008 57: 1814 -1823. First published on April 21, 2008 as 10.2337/db07-1750 [Abstract] [Full Text] [PDF] Online-Only Appendix  

Obesity Studies:

Adiponectin Reduces Plasma Triglyceride by Increasing VLDL Triglyceride Catabolism

Liping Qiao, Chenhui Zou, Deneys R. van der Westhuyzen, and Jianhua Shao
Diabetes 2008 57: 1824 -1833. First published on March 28, 2008 as 10.2337/db07-0435 [Abstract] [Full Text] [PDF] Online-Only Appendix  

Hormone-Sensitive Lipase Serine Phosphorylation and Glycerol Exchange Across Skeletal Muscle in Lean and Obese Subjects: Effect of β-Adrenergic Stimulation

Johan W.E. Jocken, Carsten Roepstorff, Gijs H. Goossens, Paula van der Baan, Marleen van Baak, Wim H.M. Saris, Bente Kiens, and Ellen E. Blaak
Diabetes 2008 57: 1834 -1841. First published on April 8, 2008 as 10.2337/db07-0857 [Abstract] [Full Text] [PDF]  

Blockade of 4 Integrin Signaling Ameliorates the Metabolic Consequences of High-Fat Diet–Induced Obesity

Chloé C. Féral, Jaap G. Neels, Christiane Kummer, Marina Slepak, Jerrold M. Olefsky, and Mark H. Ginsberg
Diabetes 2008 57: 1842 -1851. First published on April 21, 2008 as 10.2337/db07-1751 [Abstract] [Full Text] [PDF] Online-Only Appendix  

Immunology and Transplantation:

Weak Proinsulin Peptide–Major Histocompatibility Complexes Are Targeted in Autoimmune Diabetes in Mice

Matteo G. Levisetti, Danna M. Lewis, Anish Suri, and Emil R. Unanue
Diabetes 2008 57: 1852 -1860. First published on April 8, 2008 as 10.2337/db08-0068 [Abstract] [Full Text] [PDF]  

Protective Role of Programmed Death 1 Ligand 1 (PD-L1)in Nonobese Diabetic Mice: The Paradox in Transgenic Models

Chia-Jen Wang, Feng-Cheng Chou, Chi-Hong Chu, Jen-Chine Wu, Shih-Hua Lin, Deh-Ming Chang, and Huey-Kang Sytwu
Diabetes 2008 57: 1861 -1869. First published on April 16, 2008 as 10.2337/db07-1260 [Abstract] [Full Text] [PDF]  

Improved Vascular Engraftment and Graft Function After Inhibition of the Angiostatic Factor Thrombospondin-1 in Mouse Pancreatic Islets

Johan Olerud, Magnus Johansson, Jack Lawler, Nils Welsh, and Per-Ola Carlsson
Diabetes 2008 57: 1870 -1877. First published on April 16, 2008 as 10.2337/db07-0724 [Abstract] [Full Text] [PDF]  

Immunoglobulin-Like Transcript 3-Fc Suppresses T-Cell Responses to Allogeneic Human Islet Transplants in hu-NOD/SCID Mice

George Vlad, Vivette D. D'Agati, Qing-Yin Zhang, Zhuoru Liu, Eric K. Ho, Thalachallour Mohanakumar, Mark A. Hardy, Raffaello Cortesini, and Nicole Suciu-Foca
Diabetes 2008 57: 1878 -1886. First published on April 16, 2008 as 10.2337/db08-0054 [Abstract] [Full Text] [PDF]  

Islet Studies:

Fructose-1,6-Bisphosphatase Overexpression in Pancreatic β-Cells Results in Reduced Insulin Secretion: A New Mechanism for Fat-Induced Impairment of β-Cell Function

Melkam Kebede, Jenny Favaloro, Jenny E. Gunton, D. Ross Laybutt, Margaret Shaw, Nicole Wong, Barbara C. Fam, Kathryn Aston-Mourney, Christian Rantzau, Anthony Zulli, Joseph Proietto, and Sofianos Andrikopoulos
Diabetes 2008 57: 1887 -1895. First published on March 28, 2008 as 10.2337/db07-1326 [Abstract] [Full Text] [PDF]  

MAPK Kinase Kinase-1 Is Essential for Cytokine-Induced c-Jun NH₂-Terminal Kinase and Nuclear Factor-B Activation in Human Pancreatic Islet Cells

Dariush Mokhtari, Jason W. Myers, and Nils Welsh
Diabetes 2008 57: 1896 -1904. First published on April 16, 2008 as 10.2337/db07-1670 [Abstract] [Full Text] [PDF]  

Pathophysiology:

Effect of Oral Amino Acids on Counterregulatory Responses and Cognitive Function During Insulin-Induced Hypoglycemia in Nondiabetic and Type 1 Diabetic People

Paolo Rossetti, Francesca Porcellati, Natalia Busciantella Ricci, Paola Candeloro, Patrizia Cioli, K. Sreekumaran Nair, Fausto Santeusanio, Geremia B. Bolli, and Carmine G. Fanelli
Diabetes 2008 57: 1905 -1917. First published on April 4, 2008 as 10.2337/db08-0276 [Abstract] [Full Text] [PDF]  

Circulating Retinol-Binding Protein-4 Concentration Might Reflect Insulin Resistance–Associated Iron Overload

José Manuel Fernández-Real, José María Moreno, and Wifredo Ricart
Diabetes 2008 57: 1918 -1925. First published on April 21, 2008 as 10.2337/db08-0041 [Abstract] [Full Text] [PDF]  

Protein Engineering Strategies for Sustained Glucagon-Like Peptide-1 Receptor–Dependent Control of Glucose Homeostasis

Kristen M. Picha, Mark R. Cunningham, Daniel J. Drucker, Ashok Mathur, Tatiana Ort, Michael Scully, Avery Soderman, Tracy Spinka-Doms, Vedrana Stojanovic-Susulic, Beth Ann Thomas, and Karyn T. O'Neil
Diabetes 2008 57: 1926 -1934. First published on April 21, 2008 as 10.2337/db07-1775 [Abstract] [Full Text] [PDF]  

Novel De Novo Mutation in Sulfonylurea Receptor 1 Presenting as Hyperinsulinism in Infancy Followed by Overt Diabetes in Early Adolescence

Maha Abdulhadi-Atwan, Jeremy D. Bushman, Sharona Tornovsky-Babaey, Avital Perry, Abdulsalam Abu-Libdeh, Benjamin Glaser, Show-Ling Shyng, and David H. Zangen
Diabetes 2008 57: 1935 -1940. First published on April 4, 2008 as 10.2337/db08-0159 [Abstract] [Full Text] [PDF]  

Complications:

RAGE and Modulation of Ischemic Injury in the Diabetic Myocardium

Loredana G. Bucciarelli, Radha Ananthakrishnan, Yuying C. Hwang, Michiyo Kaneko, Fei Song, David R. Sell, Christopher Strauch, Vincent M. Monnier, Shi Fang Yan, Ann Marie Schmidt, and Ravichandran Ramasamy
Diabetes 2008 57: 1941 -1951. First published on April 16, 2008 as 10.2337/db07-0326 [Abstract] [Full Text] [PDF]  

Hyperglycemia-Induced Reactive Oxygen Species Toxicity to Endothelial Cells Is Dependent on Paracrine Mediators

Julia V. Busik, Susanne Mohr, and Maria B. Grant
Diabetes 2008 57: 1952 -1965. First published on April 16, 2008 as 10.2337/db07-1520 [Abstract] [Full Text] [PDF]  

Serum Heat Shock Protein 27 and Diabetes Complications in the EURODIAB Prospective Complications Study: A Novel Circulating Marker for Diabetic Neuropathy

Gabriella Gruden, Graziella Bruno, Nish Chaturvedi, Davina Burt, Casper Schalkwijk, Silvia Pinach, Coen D. Stehouwer, Daniel R. Witte, John H. Fuller, Paolo Cavallo Perin, and the EURODIAB Prospective Complications Study Group
Diabetes 2008 57: 1966 -1970. First published on April 4, 2008 as 10.2337/db08-0009 [Abstract] [Full Text] [PDF]  

Genetics:

Haplotype Structure of the ENPP1 Gene and Nominal Association of the K121Q Missense Single Nucleotide Polymorphism With Glycemic Traits in the Framingham Heart Study

Elliot S. Stolerman, Alisa K. Manning, Jarred B. McAteer, Josée Dupuis, Caroline S. Fox, L. Adrienne Cupples, James B. Meigs, and Jose C. Florez
Diabetes 2008 57: 1971 -1977. First published on April 21, 2008 as 10.2337/db08-0266 [Abstract] [Full Text] [PDF] Online-Only Appendix  

Diabetes Susceptibility in the Canadian Oji-Cree Population Is Moderated by Abnormal mRNA Processing of HNF1A G319S Transcripts

Lorna W. Harries, Melissa J. Sloman, Elizabeth A.C. Sellers, Andrew T. Hattersley, and Sian Ellard
Diabetes 2008 57: 1978 -1982. First published on April 14, 2008 as 10.2337/db07-1633 [Abstract] [Full Text] [PDF]  

Association Analysis of Type 2 Diabetes Loci in Type 1 Diabetes

Hui-Qi Qu, Struan F.A. Grant, Jonathan P. Bradfield, Cecilia Kim, Edward Frackelton, Hakon Hakonarson, and Constantin Polychronakos
Diabetes 2008 57: 1983 -1986. First published on April 21, 2008 as 10.2337/db08-0270 [Abstract] [Full Text] [PDF] Online-Only Appendix  

Association of FTO With Obesity-Related Traits in the Cebu Longitudinal Health and Nutrition Survey (CLHNS) Cohort

Amanda F. Marvelle, Leslie A. Lange, Li Qin, Linda S. Adair, and Karen L. Mohlke
Diabetes 2008 57: 1987 -1991. First published on April 21, 2008 as 10.2337/db07-1700 [Abstract] [Full Text] [PDF] Online-Only Appendix  

Evaluation of the Association of IGF2BP2 Variants With Type 2 Diabetes in French Caucasians

Konsta Duesing, Ghazaleh Fatemifar, Guillaume Charpentier, Michel Marre, Jean Tichet, Serge Hercberg, Beverley Balkau, Philippe Froguel, and Fernando Gibson
Diabetes 2008 57: 1992 -1996. First published on April 22, 2008 as 10.2337/db07-1789 [Abstract] [Full Text] [PDF] Online-Only Appendix  

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