Online Ahead of Print

Last updated November 23, 2009

To make new research readily available to our subscribers, Diabetes prepublishes all accepted manuscripts as soon as possible after acceptance. These papers have undergone full peer review, but they have yet to undergo copyediting, typesetting, and proofreading. The final versions of these papers will appear in a future print and online issue of Diabetes; they can be cited using the accompanying DOI. If you are interested in commenting on one of these articles, the editors ask that you wait until the final version has appeared in print before submitting your commentary or letter to the editor.

November 10, 2009

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Original Research:

Hongfang Lu,
Vasilij Koshkin,
Emma M. Allister,
Armen V. Gyulkhandanyan,
and Michael B. Wheeler

Molecular and Metabolic Evidence for Mitochondrial Defects Associated With β-Cell Dysfunction in a mouse model of Type 2 Diabetes Diabetes ; published ahead of print November 10, 2009, doi:10.2337/db09-0129

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Original Research:

John P. Driver,
Felix Scheuplein,
Yi-Guang Chen,
Alexandra E. Grier,
S. Brian Wilson,
and David V. Serreze

iNKT-cell control of Type-1 Diabetes: a Dendritic Cell Genetic Decision of a Silver Bullet or Russian Roulette Diabetes ; published ahead of print November 10, 2009, doi:10.2337/db09-1116

October 29, 2009

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Original Research:

Maria Tikhonenko,
Todd A. Lydic,
Yun Wang,
Weiqin Chen,
Madalina Opreanu,
Andrew Sochacki,
Kelly M. McSorley,
Rebecca L. Renis,
Timothy Kern,
Donald B. Jump,
Gavin E. Reid,
and Julia V. Busik

Remodeling of Retinal Fatty Acids in an Animal Model of Diabetes: a Decrease in Long Chain Polyunsaturated Fatty Acids is Associated with a Decrease in Fatty Acid Elongases Elovl2 and Elovl4. Diabetes ; published ahead of print October 29, 2009, doi:10.2337/db09-0728

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Original Research:

S Alice Long,
Karen Cerosaletti,
Paul L. Bollyky,
Megan Tatum,
Heather Shilling,
Sheng Zhang,
Zhong-Yin Zhang,
Catherine Pihoker,
Srinath Sanda,
Carla Greenbaum,
and Jane H Buckner

Defects in IL-2R signaling contribute to diminished maintenance of FOXP3 expression in CD4⁺CD25⁺ regulatory T cells of T1D subjects Diabetes ; published ahead of print October 29, 2009, doi:10.2337/db09-0694

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Original Research:

Andrew D. Paterson,
Daryl Waggott,
Andrew P. Boright,
S. Mohsen Hosseini,
Enqing Shen,
Marie-Pierre Sylvestre,
Isidro Wong,
Bhupinder Bharaj,
Patricia A. Cleary,
John M. Lachin,
MAGIC,
Jennifer E. Below,
Dan Nicolae,
Nancy J. Cox,
Angelo J. Canty,
Lei Sun,
Shelley B. Bull,
and The Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Research Group

A genome-wide association study identifies a novel major locus for glycemic control in type 1 diabetes, as measured by both HbA1c and glucose. Diabetes ; published ahead of print October 29, 2009, doi:10.2337/db09-0653

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Original Research:

Junqin Chen,
Ghislaine Fontes,
Geetu Saxena,
Vincent Poitout,
and Anath Shalev

Lack of TXNIP protects against mitochondria-mediated apoptosis, but not against fatty acid-induced, ER-stress-mediated beta cell death Diabetes ; published ahead of print October 29, 2009, doi:10.2337/db09-0949

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Original Research:

Chris R Cardwell,
Lars C Stene,
Geir Joner,
Max K Bulsara,
Ondrej Cinek,
Joachim Rosenbauer,
Johnny Ludvigsson,
Mireia Jané,
Jannet Svensson,
Michael J Goldacre,
Thomas Waldhoer,
Przemysława Jarosz-Chobot,
Suely GA Gimeno,
Lee-Ming Chuang,
Roger C Parslow,
Emma JK Wadsworth,
Amanda Chetwynd,
Paolo Pozzilli,
Girts Brigis,
Brone Urbonaitė,
Sandra Šipetić,
Edith Schober,
Gabriele Devoti,
Constantin Ionescu-Tirgoviste,
Carine E de Beaufort,
Denka Stoyanov,
Karsten Buschard,
and Chris C Patterson

Maternal age at birth and childhood type 1 diabetes: a pooled analysis of 30 observational studies Diabetes ; published ahead of print October 29, 2009, doi:10.2337/db09-1166

October 28, 2009

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Original Research:

Virve M Lundgren,
Bo Isomaa,
Valeriya Lyssenko,
Esa Laurila,
Pasi Korhonen,
Leif C Groop,
Tiinamaija Tuomi,
and for the Botnia Study Group

GADA positivity predicts non-insulin dependent diabetes in an adult population Diabetes ; published ahead of print October 28, 2009, doi:10.2337/db09-0747

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Original Research:

Alessia Fornoni,
Jongmin Jeon,
Javier Varona Santos,
Lorenzo Cobianchi,
Alexandra Jauregui,
Luca Inverardi,
Slavena A. Mandic,
Christina Bark,
Kevin Johnson,
George McNamara,
Antonello Pileggi,
R. Damaris Molano,
Jochen Reiser,
Karl Tryggvason,
Dontscho Kerjaschki,
Per-Olof Berggren,
Peter Mundel,
and Camillo Ricordi

Nephrin is expressed on the surface of insulin vesicles and facilitates glucose stimulated insulin release Diabetes ; published ahead of print October 15, 2009, doi:10.2337/db09-0655

October 21, 2009

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Original Research:

Erik Arner,
Pål O Westermark,
Kirsty L Spalding,
Tom Britton,
Mikael Rydén,
Jonas Frisén,
Samuel Bernard,
and Peter Arner

ADIPOCYTE TURNOVER: RELEVANCE TO HUMAN ADIPOSE TISSUE MORPHOLOGY Diabetes ; published ahead of print October 21, 2009, doi:10.2337/db09-0942

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Original Research:

Manuel Sanchez-Alavez,
Iustin V. Tabarean,
Olivia Osborn,
Kayo Mitsukawa,
Jean Schaefer,
Jeffrey Dubins,
Kristina H Holmberg,
Izabella Klein,
Joe Klaus,
Luis F Gomez,
Hartmuth Kolb,
James Secrest,
Jeanine Jochems,
Kevin Myashiro,
Peter Buckley,
John R Hadcock,
James Eberwine,
Bruno Conti,
and Tamas Bartfai

Insulin causes hyperthermia by direct inhibition of warm sensitive neurons Diabetes ; published ahead of print October 21, 2009, doi:10.2337/db09-1128

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Original Research:

Inagadapa J.N. Padmavathi,
Kalashikam Rajender Rao,
Lagishetty Venu,
Manisha Ganeshan,
K. Anand Kumar,
Ch. Narasimha Rao,
Nemani Harishankar,
Ayesha Ismail,
and Manchala Raghunath

Chronic maternal dietary chromium restriction modulates visceral adiposity: probable underlying mechanisms Diabetes ; published ahead of print October 21, 2009, doi:10.2337/db09-0779

October 13, 2009

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Original Research:

Anita M. Hennige,
Felicia Ranta,
Isabel Heinzelmann,
Martina Düfer,
Diana Michael,
Heidi Braumüller,
Stefan Z. Lutz,
Reiner Lammers,
Gisela Drews,
Fatima Bosch,
Hans-Ulrich Häring,
and Susanne Ullrich

Over-expression of kinase negative protein kinase Cδ in pancreatic β-cells protects mice from diet-induced glucose intolerance and β-cell dysfunction Diabetes ; published ahead of print October 13, 2009, doi:10.2337/db09-0512

October 6, 2009

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Original Research:

Leen M. ‘t Hart,
Annemarie M. Simonis-Bik,
Giel Nijpels,
Timon W. van Haeften,
Silke A. Schäfer,
Jeanine J. Houwing-Duistermaat,
Dorret I. Boomsma,
Marlous J. Groenewoud,
Erwin Reiling,
Els C van Hove,
Michaela Diamant,
Mark H.H. Kramer,
Robert J. Heine,
J. Antonie Maassen,
Kerstin Kirchhoff,
Fausto Machicao,
Hans-Ulrich Häring,
P. Eline Slagboom,
Gonneke Willemsen,
Elisabeth M. Eekhoff,
Eco J. de Geus,
Jacqueline M. Dekker,
and Andreas Fritsche

A Combined Risk Allele Score of Eight Type 2 Diabetes Genes Is Associated With Reduced First Phase Glucose Stimulated Insulin Secretion During Hyperglycemic Clamps Diabetes ; published ahead of print October 6, 2009, doi:10.2337/db09-0736

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Original Research:

Michela Slucca,
Jamie S. Harmon,
Elizabeth A. Oseid,
Joseph Bryan,
and R. Paul Robertson

K_ATP channel mediates the zinc switch-off signal for glucagon response during glucose deprivation Diabetes ; published ahead of print October 6, 2009, doi:10.2337/db09-1098

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Original Research:

Jennifer Jager,
Thierry Grémeaux,
Teresa Gonzalez,
Stéphanie Bonnafous,
Cyrille Debard,
Martine Laville,
Hubert Vidal,
Albert Tran,
Philippe Gual,
Yannick Le Marchand-Brustel,
Mireille Cormont,
and Jean-François Tanti

The Tpl2 kinase is up-regulated in adipose tissue in obesity and may mediate IL-1β and TNF-α effects on ERK activation and lipolysis Diabetes ; published ahead of print October 6, 2009, doi:10.2337/db09-0470

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Original Research:

Pia Thaning,
Laurids T Bune,
Ylva Hellsten,
Henriette Pilegaard,
Bengt Saltin,
and Jaya B Rosenmeier

Attenuated Purinergic Receptor Function in Patients with Type 2 Diabetes Diabetes ; published ahead of print October 6, 2009, doi:10.2337/db09-1068

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Original Research:

Risheng Ye,
Dae Young Jung,
John Y. Jun,
Jianze Li,
Shengzhan Luo,
Hwi Jin Ko,
Jason K. Kim,
and Amy S. Lee

Grp78 Heterozygosity Promotes Adaptive Unfolded Protein Response and Attenuates Diet-Induced Obesity and Insulin Resistance Diabetes ; published ahead of print October 6, 2009, doi:10.2337/db09-0755

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Original Research:

Weiguo Li,
Roshini Prakash,
Aisha I Kelly-Cobbs,
Safia Ogbi,
Anna Kozak,
Azza B El-Remessy,
Derek A Schreihofer,
Susan C Fagan,
and Adviye Ergul

Adaptive Cerebral Neovascularization in a Model of Type 2 Diabetes: Relevance to Focal Cerebral Ischemia Diabetes ; published ahead of print October 6, 2009, doi:10.2337/db09-0902

September 30, 2009

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Original Research:

Nehal N. Mehta,
Fiona C. McGillicuddy,
Paul D. Anderson,
Christine C. Hinkle,
Rachana Shah,
Leticia Pruscino,
Jennifer Tabita-Martinez,
Kim F. Sellers,
Michael R. Rickels,
and Muredach P. Reilly

Experimental Endotoxemia Induces Adipose Inflammation and Insulin Resistance in Humans Diabetes ; published ahead of print September 30, 2009, doi:10.2337/db09-0367

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Original Research:

Jacqueline F. Aitken,
Kerry M. Loomes,
David W. Scott,
Shivanand Reddy,
Anthony R.J. Phillips,
Gordana Prijic,
Chathurini Fernando,
Shaoping Zhang,
Ric Broadhurst,
Phil L'Huillier,
and Garth J.S. Cooper

Tetracycline treatment retards the onset and slows the progression of diabetes in human amylin/hIAPP transgenic mice Diabetes ; published ahead of print September 30, 2009, doi:10.2337/db09-0548

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Original Research:

Samson Mathews Samuel,
Yuzo Akita,
Debayon Paul,
Mahesh Thirunavukkarasu,
Lijun Zhan,
Perumana R. Sudhakaran,
Chuanfu Li,
and Nilanjana Maulik

Co-administration of Adenoviral VEGF and Ang-1 Enhances Vascularization and Reduces Ventricular Remodeling in the Infarcted Myocardium of Type I Diabetic Rats Diabetes ; published ahead of print September 30, 2009, doi:10.2337/db09-0336

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Original Research:

Nehal N. Mehta,
Fiona C. McGillicuddy,
Paul D. Anderson,
Christine C. Hinkle,
Rachana Shah,
Leticia Pruscino,
Jennifer Tabita-Martinez,
Kim F. Sellers,
Michael R. Rickels,
and Muredach P. Reilly

Experimental Endotoxemia Induces Adipose Inflammation and Insulin Resistance in Humans Diabetes ; published ahead of print September 30, 2009, doi:10.2337/db09-0729

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Original Research:

Rebecca S. Tirabassi,
Dennis L. Guberski,
Elizabeth P. Blankenhorn,
Jean H. Leif,
Bruce A. Woda,
Zhijun Liu,
Donald Winans,
Dale L. Greiner,
and John P. Mordes

INFECTION WITH VIRUSES FROM SEVERAL FAMILIES TRIGGERS AUTOIMMUNE DIABETES IN LEW.1WR1 RATS: Prevention of Diabetes by Maternal Immunization Diabetes ; published ahead of print September 30, 2009, doi:10.2337/db09-0255

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Original Research:

Hana Lango Allen,
Stefan Johansson,
Sian Ellard,
Beverley Shields,
Jens K Hertel,
Helge Ræder,
Kevin Colclough,
Anders Molven,
Timothy M Frayling,
Pål R Njølstad,
Andrew T Hattersley,
and Michael N Weedon

Polygenic Risk Variants for Type 2 Diabetes Susceptibility Modify Age at Diagnosis in Monogenic HNF1A Diabetes Diabetes ; published ahead of print September 30, 2009, doi:10.2337/db09-0555

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Original Research:

Clive J. Petry,
Mark L. Evans,
Dianne L. Wingate,
Ken K. Ong,
Wolf Reik,
Miguel Constância,
and David B. Dunger

Raised Late Pregnancy Glucose Concentrations in Mice carrying Pups with Targeted Disruption of H19^Δ13 Diabetes ; published ahead of print September 30, 2009, doi:10.2337/db09-0757

September 15, 2009

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Original Research:

Takayuki Miki,
Tetsuji Miura,
Hiroyuki Hotta,
Masaya Tanno,
Toshiyuki Yano,
Takahiro Sato,
Yoshiaki Terashima,
Akifumi Takada,
Satoko Ishikawa,
and Kazuaki Shimamoto

ER stress in diabetic hearts abolishes erythropoietin-induced myocardial protection by impairment of phospho-GSK-3β-mediated suppression of mitochondrial permeability transition. Diabetes ; published ahead of print September 15, 2009, doi:10.2337/db09-0158

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Original Research:

Heli TA Siljander,
Satu Simell,
Anne Hekkala,
Jyrki Lähde,
Tuula Simell,
Paula Vähäsalo,
Riitta Veijola,
Jorma Ilonen,
Olli Simell,
and Mikael Knip

Predictive Characteristics of Diabetes-Associated Autoantibodies Among Children With HLA-Conferred Disease Susceptibility in the General Population Diabetes ; published ahead of print September 15, 2009, doi:10.2337/db08-1305

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Original Research:

Dale S. Edgerton,
Christopher J. Ramnanan,
Carrie A. Grueter,
Kathryn M. S. Johnson,
Margaret Lautz,
Doss W. Neal,
Phillip E. Williams,
and Alan D. Cherrington

Effects of Insulin on the Metabolic Control of Hepatic Gluconeogenesis in vivo Diabetes ; published ahead of print September 15, 2009, doi:10.2337/db09-0328

September 14, 2009

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Original Research:

Chitoku Toda,
Tetsuya Shiuchi,
Suni Lee,
Maya Yamato-Esaki,
Yusuke Fujino,
Atsushi Suzuki,
Shiki Okamoto,
and Yasuhiko Minokoshi

Distinct effects of leptin and a melanocortin receptor agonist injected into medial hypothalamic nuclei on glucose uptake in peripheral tissues Diabetes ; published ahead of print September 14, 2009, doi:10.2337/db09-0638

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Original Research:

Jian H. Li,
Dinesh Gautam,
Sung-Jun Han,
Jean-Marc Guettier,
Yinghong Cui,
Huiyan Lu,
Chuxia Deng,
James O'Hare,
William Jou,
Oksana Gavrilova,
Christoph Buettner,
and Jürgen Wess

Hepatic Muscarinic Acetylcholine Receptors are not Critically Involved in Maintaining Glucose Homeostasis in Mice Diabetes ; published ahead of print September 14, 2009, doi:10.2337/db09-0522

September 9, 2009

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Original Research:

Lily C. Chao,
Kevin Wroblewski,
Zidong Zhang,
Liming Pei,
Laurent Vergnes,
Olga R. Ilkayeva,
Shiying Ding,
Karen Reue,
Matthew J. Watt,
Christopher B. Newgard,
Paul F. Pilch,
Andrea L. Hevener,
and Peter Tontonoz

Insulin resistance and altered systemic glucose metabolism in mice lacking Nur77 Diabetes ; published ahead of print September 9, 2009, doi:10.2337/db09-0763

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Original Research:

Xia Li,
Yu-Hsiang Shu,
Anny H. Xiang,
Enrique Trigo,
Johanna Kuusisto,
Jaana Hartiala,
Amy J. Swift,
Miwa Kawakubo,
Heather M. Stringham,
Lori L. Bonnycastle,
Jean M. Lawrence,
Markku Laakso,
Hooman Allayee,
Thomas A. Buchanan,
and Richard M. Watanabe

ADDITIVE EFFECTS OF GENETIC VARIATION IN GCK AND G6PC2 ON INSULIN SECRETION AND FASTING GLUCOSE Diabetes ; published ahead of print September 9, 2009, doi:10.2337/db09-0228

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Original Research:

Jide Tian,
Hoa Dang,
Harald von Boehmer,
Elmar Jaeckel,
and Daniel L. Kaufman

Transgenically-induced GAD tolerance curtails the development of early ß-cell autoreactivities but causes the subsequent development of supernormal autoreactivities to other ß-cell antigens Diabetes ; published ahead of print September 9, 2009, doi:10.2337/db08-0851

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Original Research:

M. Carola Zillikens,
Joyce B.J. van Meurs,
Fernando Rivadeneira,
Najaf Amin,
Albert Hofman,
Ben A Oostra,
Eric J.G. Sijbrands,
Jacqueline C.M. Witteman,
Huibert A.P. Pols,
Cornelia M. van Duijn,
and André G. Uitterlinden

SIRT1 genetic variation is related to body mass index and risk of obesity Diabetes ; published ahead of print September 9, 2009, doi:10.2337/db09-0536

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Original Research:

Clara Kelliny,
Ulf Ekelund,
Lars Bo Andersen,
Soren Brage,
Ruth J. F. Loos,
Nicholas J. Wareham,
and Claudia Langenberg

Common Genetic Determinants of Glucose Homeostasis in Healthy Children: The European Youth Heart Study (EYHS) Diabetes ; published ahead of print September 9, 2009, doi:10.2337/db09-0374

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Original Research:

Jason G. Barrera,
David A. D'Alessio,
Daniel J. Drucker,
Stephen C. Woods,
and Randy J. Seeley

Differences in the central anorectic effects of GLP-1 and exendin-4 in rats Diabetes ; published ahead of print September 9, 2009, doi:10.2337/db09-0281

August 20, 2009

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Original Research:

Patricia O. Prada,
Eduardo R. Ropelle,
Rosa H. Mourão,
Claudio T. de Souza,
Jose R. Pauli,
Dennys E. Cintra,
André Schenka,
Silvana A. Rocco,
Roberto Rittner,
Kleber G. Franchini,
José Vassalo,
Lício A. Velloso,
José B. Carvalheira,
and Mario J.A. Saad

An EGFR Tyrosine-Kinase Inhibitor (PD153035) Improves Glucose Tolerance and Insulin Action in High-Fat Diet-Fed Mice. Diabetes ; published ahead of print August 20, 2009, doi:10.2337/db08-0506

August 18, 2009

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Original Research:

Kazutoshi Miyashita,
Hiroshi Itoh,
Hirokazu Tsujimoto,
Naohisa Tamura,
Yasutomo Fukunaga,
Masakatsu Sone,
Kenichi Yamahara,
Daisuke Taura,
Megumi Inuzuka,
Takuhiro Sonoyama,
and Kazuwa Nakao

Natriuretic Peptides/cGMP/cGMP-dependent Protein Kinase Cascades Promote Muscle Mitochondrial Biogenesis and Prevent Obesity. Diabetes ; published ahead of print August 18, 2009, doi:10.2337/db09-0393

February 19, 2009

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Original Research:

Kae Nagasumi,
Ritsuko Esaki,
Kimihiko Iwachidow,
Yoshitaka Yasuhara,
Kazuhiro Ogi,
Hideyuki Tanaka,
Mitsugu Nakata,
Takashi Yano,
Kozo Shimakawa,
Shigehisa Taketomi,
Koji Takeuchi,
Hiroyuki Odaka,
and Yoshihiko Kaisho

Overexpression of GPR40 in Pancreatic β-Cells Augments Glucose Stimulated Insulin Secretion and Improves Glucose Tolerance in Normal and Diabetic Mice Diabetes ; published ahead of print February 10, 2009, doi:10.2337/db09-1233

August 8, 2007

Original Research:

Lijun Ma,
Robert L. Hanson,
Lorem N. Que,
Anna M. G. Cali,
Mao Fu,
Janel L. Mack,
Aniello M. Infante,
Sayuko Kobes,
Clifton Bogardus,
Alan R. Shuldiner,
and Leslie J. Baier

Variants in ARHGEF11, a Candidate Gene for the Linkage to Type 2 Diabetes Mellitus on Chromosome 1q, Are Nominally Associated With Insulin Resistance and Type 2 Diabetes Mellitus in Pima Indians Diabetes ; published ahead of print January 29, 2007, doi:10.2337/db07-0640

Original Research:

Daniel Johnson,
Ruth M Shepherd,
Debra Gill,
Tracy Gorman,
David M Smith,
and Mark J Dunne

GLUCOSE-DEPENDENT MODULATION OF INSULIN SECRETION AND INTRACELLULAR CALCIUM IONS BY GKA50 - A GLUCOKINASE ACTIVATOR Diabetes ; published ahead of print March 9, 2007, doi:10.2337/db07-0027

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July 31, 2007

Original Research:

Rodolfo Valdez,
Paula W. Yoon,
Tiebin Liu,
and Muin J. Khoury

Family history and prevalence of diabetes in the US population: 6-year results from the National Health and Nutrition Examination Survey (NHANES, 1999–2004) Diabetes ; published ahead of print July 31, 2007, doi:10.2337/db07-0720x

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Current Issue

November 2009, 58 (11)

Online Ahead of Print

November 23, 2009

November 10, 2009

October 29, 2009

October 28, 2009

October 21, 2009

October 15, 2009

October 13, 2009

October 6, 2009

September 30, 2009

September 15, 2009

September 14, 2009

September 9, 2009

August 31, 2009

August 20, 2009

August 18, 2009

February 19, 2009

August 8, 2007

July 31, 2007

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